Guthion -- EPA Technical Summary for
EPA is scheduled to hold a public meeting and
technical briefing on May 19, 1999. The following appeared on their web site
as of May18th:
Azinphos-methyl is used on a wide variety
of fruit and vegetable crops, tree crops, grains, cotton, and ornamentals.
Azinphos-methyl is a restricted use pesticide applied aerially and by ground
On average, two million pounds of azinphos-methyl are applied annually.
Azinphos-methyl can cause cholinesterase inhibition in humans; that is, it can
overstimulate the nervous system causing nausea, dizziness, confusion, and at high
exposures, respiratory paralysis and death.
Dietary Risk is high from acute exposure.
The acute risk assessment is highly refined using USDA Pesticide Data Program
(PDP) data, that reflects actual use of pesticides and FDA monitoring for most
At the 99.9th percentile, acute risks for infants and children are of concern. At
the 99.8th percentile, risk for the general population and all subpopulations is not
of concern. At the 99.9th percentile, the risk is not driven by an individual with an
extreme consumption pattern nor by an unusual residue level.
Apple consumption is clearly the major contributor to risk followed by peaches
and pears. All scenarios evaluated that include apples result inacute risk which is of
concern to at least one subpopulation. Without apples, acute risk to all subpopulations is
not of concern at the 99.9th percentile.
Chronic risk is not a concern.
Worker Risk is very high.
For mixers, loaders, and applicators, risks for most exposure scenarios evaluated
are of concern even with maximum PPE/engineering controls. For exposure scenarios which
have risks of concern, estimated MOEs range from <1 to 90.
For most crops,post-application risk, at the current restricted entry intervals
(REIs), is of concern. For many crops, to achieve risk estimates that are not of
concern, REIs would be too long to be practical for crop production.
Drinking Water Risk is uncertain.
Acute exposure will add to the dietary risk, which is already a risk concern.
Chronic exposure does not appear to be of concern.
Aggregate Risk is of concern from acute exposure.
Aggregate acute risk is of concern because food alone is of concern and
water will only make the exceedance larger.
Aggregate chronic risk (food and water) is not of concern.
Ecological Risks are high.
The preliminary risk assessment indicates that risk to aquatic organisms is very
high and risk to terrestrial organisms is also of concern.
How the Risk Picture May Change
An apple cooking study on baby food could reduce the estimated dietary risk.
For additional information on EPA's summary contact: Chemical Review Manager, Barry